Accession Number : AD0712664

Title :   COMBINED EFFECTS OF CHLORPROMAZINE AND ALTITUDE UPON PERFORMANCE IN THE RAT.

Descriptive Note : Rept. for Jan-Mar 70,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Dasher,Charles E. ; Hamilton,Horace E.

Report Date : AUG 1970

Pagination or Media Count : 17

Abstract : Four male Sprague-Dawley rats were conditioned to press a lever in response to visual and auditory cues, and to release the lever upon termination of the cues. The rodents were then tested under the conditions of saline, chlorpromazine (CPZ), altitude, and CPZ plus altitude. For each set of data, 50 trials of control data were recorded, and then the animals were either injected with saline or CPZ, or, in the case of controls, merely stuck with a needle. Twenty-five minutes after injection, an additional 50 trials were recorded. For the altitude data, the rodents were brought to the simulated altitude 5 minutes after injection. Performance was significantly decreased by CPZ (P < .01) and by altitude (P < .05), but no CPZ-altitude interactions were observed. Saline produced no effect upon performance. (Author)

Descriptors :   (*CHLORPROMAZINE, *PERFORMANCE(HUMAN)), (*HIGH ALTITUDE, PERFORMANCE(HUMAN)), RATS, CONDITIONED RESPONSE, EFFECTIVENESS

Subject Categories : Stress Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE