Accession Number : AD0712965

Title :   EVALUATION OF HUMAN PLASMA AFTER PROLONGED STORAGE IN PLASTIC CONTAINERS.

Descriptive Note : Final rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Shields,Charles E. ; Castaneda,Ben F.

Report Date : 07 MAY 1970

Pagination or Media Count : 14

Abstract : The plasma was stored for 2-5 years at room temperature, at 3-6C, or at -18C. Samples from the stored plasma were tested for bacterial contamination, chemical and protein content. None of the samples showed bacterial growth. None of the samples had plasma hemoglobin values over 25 mg/100 ml, although the pooled unit group had a slightly higher average than the single unit group. Electrolyte values were within the range found in whole blood after 21 days' storage. Total protein was within the normal range, although protein electrophoresis detected minor differences in distribution. A decrease in fibrinogen with age was observed and confirmed by specific immunoelectrophoresis. Minor increase in alpha 2 and beta globulin on electrophoresis was felt to reflect contamination from residual fibrinogen fragments migrating in the same area. The deterioration of fibrinogen appeared to be aggravated by storage at room temperature. Thus, the use of frozen plasma would appear to be more effective, although the overall changes detected would suggest that plasma can still remain usable after 4-5 years of storage. (Author)

Descriptors :   (*BLOOD PLASMA, STORAGE), EFFECTIVENESS, BIOLOGICAL CONTAMINATION, PROTEINS, ELECTROLYTES, TEMPERATURE, FREEZING, FIBRINOGEN, GLOBULINS

Subject Categories : Medical Facilities, Equipment and Supplies

Distribution Statement : APPROVED FOR PUBLIC RELEASE