Accession Number : AD0712968

Title :   IMMUNOCHEMICAL ANALYSIS OF TRANSPLANTATION ANTIGENS IN XENOGENIC KERATOPLASTY.

Descriptive Note : Interim rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Luzzio,Anthony J. ; Leibowitz,Howard M.

Report Date : 26 MAY 1970

Pagination or Media Count : 18

Abstract : Preimmunization of rabbits with chicken corneal extracts causes subsequent xenogenic corneal grafts to be rejected more violently and more rapidly than similar grafts in unmodified control animals. By definition, therefore, these extracts contain transplantation antigens. Immunization with these extracts also induces the formation of both precipitating and hemolyzing antibodies. Keratoplasty performed 6 weeks after immunization, when the antibody titers have declined measurably, produces an anamnestic precipitin response but fails to elicit a similar response for hemolysins. Evidence is presented indicating that in addition to transplantation antigens, the corneal extracts contain the Forssman antigen. The latter is responsible for the hemolysin response and has no relation to immunogenic rejection of the corneal graft. (Author)

Descriptors :   (*CORNEA, TRANSPLANTATION), (*TRANSPLANTATION, *ANTIGENS + ANTIBODIES), IMMUNITY, RESPONSE(BIOLOGY), HEMOLYSIS, EYE, IMMUNOLOGY

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE