Accession Number : AD0713069

Title :   DECREASED DIURESIS IN RESPONSE TO A THIAZIDE DIURETIC AT A SIMULATED ALTITUDE.

Descriptive Note : Interim rept. for Jan-Mar 70,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Sulkowski,Thomas S. ; Merritt,James H.

Report Date : AUG 1970

Pagination or Media Count : 12

Abstract : The effect of hydrochlorothiazide on the diuretic response of rats at 12,000 ft. was examined. After administration of a saline load, with and without drug, urine was collected over a 5-hr. period at both altitude and ground level. Total volume, urinary Na(+) and K(+), and pH were determined. The most pronounced effect of the altitude-drug interaction was decrease in the expected urine volume while the increased Na(+) output did not change from the observed with the drug at ground level. The results are discussed in relation to the possible basis for the observed phenomenon. (Author)

Descriptors :   (*DIURETICS, HIGH ALTITUDE), AVIATION MEDICINE, PILOTS, EFFECTIVENESS, ELECTROLYTES, STRESS(PHYSIOLOGY), PHYSIOLOGY, PHARMACOLOGY, RATS

Subject Categories : Stress Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE