Accession Number : AD0713738

Title :   INFLUENCE OF GANGLIONIC BLOCKADE ON CATECHOLAMINE AND METABOLITE EXCRETION,

Corporate Author : TORONTO UNIV (ONTARIO) DEPT OF PHARMACOLOGY

Personal Author(s) : Shum,A. ; Johnson,G. E. ; Flattery,K. V.

Report Date : 20 OCT 1969

Pagination or Media Count : 5

Abstract : Rats were placed at 28C for a control period of 4 hr prior to treatment with mecamylamine or saline. After injection the rats were divided into two groups with one group remaining at 28C and the other being placed at 15C. Ganglionic blockade with mecamylamine decreased the urinary excretion of norepinephrine and normetanephrine in both groups of rats. 3-methoxy-4-hydroxyphenyl glycol (MHPG) excretion fell in the mecamylamine-treated group kept at 28C but rose slightly in the group transferred to 15C. The fall in norepinephrine and normetanephrine excretion, seen after mecamylamine treatment, reflects a decrease in norepinephrine secretion. The increase in MHPG in the cold indicates a rise in the synthesis and intraneuronal degradation of norepinephrine. These results support our earlier postulate that the rate of norepinephrine synthesis is dependent, at least partially, on the ambient temperature and can dissociate itself from the rate of secretion. (Author)

Descriptors :   (*AUTONOMIC AGENTS, *METABOLISM), (*AMINES, *EXCRETION), GANGLIA, INHIBITION, NERVOUS SYSTEM, LEVARTERENOL, URINE, EXCRETION, NERVES, BIOSYNTHESIS, LOW TEMPERATURE, SECRETION, PHYSIOLOGY, METABOLISM

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE