Accession Number : AD0714186

Title :   Hemoglobin Function in Stored Blood. IV. Red Cell Viability and Function in ACD and CPD with Adenine and Inosine.

Descriptive Note : Progress rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Dawson,Roy B. , Jr. ; Edinger,Mildred C. ; Ellis,Thomas J.

Report Date : 30 JUN 1970

Pagination or Media Count : 14

Abstract : The importance of adenine for maintaining ATP and thus shelf life of stored blood has been reaffirmed. Studies reported here indicate that 0.25 mM adenine, or one-half the amount previously specified, may be sufficient to provide a 5-week shelf life. The initial concentration of adenine can be reduced further--to 0.125 mM, if 10 mM inosine and 0.125 mM adenine are added at 2 weeks. This use of inosine with small concentrations of adenine provides for near normal hemoglobin function as well as red cell viability during the 5-week storage period. (Author)

Descriptors :   (*BLOOD, STORAGE), HEMOGLOBIN, PRESERVATION, ADENINE, PURINES, ADENOSINE PHOSPHATES, VIABILITY, ERYTHROCYTES, NUCLEOSIDES, ACIDS, CITRATES, PHOSPHATES, GLUCOSE, STABILITY

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE