Accession Number : AD0714245

Title :   Wound Healing and Cellular Microenvironment.

Descriptive Note : Final technical rept. May 69-May 70,

Corporate Author : CAMBRIDGE UNIV (ENGLAND)

Personal Author(s) : Silver,Ian A.

Report Date : JUL 1970

Pagination or Media Count : 38

Abstract : The purpose of the work in this report was to investigate the tissue microenvironment in wounds by means of microelectrodes and spectrofluorimetric techniques with a view to measuring physical conditions which might affect the healing process. Factors affecting capillary blood flow and permeability have been studied and gradients of oxygen tension from vessel to mitochondria have been measured. The model for study has been regenerating tissue - specially modified transparent rabbit ear chambers. It has been demonstrated that very steep oxygen gradients exist in the proliferative zone and this gradient may be part of the stimulus for new growth. Many cells in this zone appear to be oxygen deprived and the supply of oxygen may be a rate limiting factor in growth. Many factors such as shock, vasoactive substances or even slight stress, reduce blood flow to wounds and worsen conditions in the growing zone. (Author)

Descriptors :   (*WOUNDS AND INJURIES, *HEALING), PHYSIOLOGY, TISSUES(BIOLOGY), BLOOD CIRCULATION, CAPILLARIES, CELLS(BIOLOGY), MITOCHONDRIA, OXYGEN, GROWTH(PHYSIOLOGY), FLUORESCENCE, CHEMICAL ANALYSIS

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE