Accession Number : AD0714372

Title :   The Synthesis of Potential 3-Phenylquinoline Antimalarials a-Aminomethyl-3-Phenyl-5-Quinolinemethanols.

Descriptive Note : Rept. no. 4 (Final), 1 Jun 69-31 May 70,

Corporate Author : SMITH KLINE AND FRENCH LABS PHILADELPHIA PA

Personal Author(s) : Wilson,James W. ; Frazee,James F. ; Makriyannis,Alexandros

Report Date : 15 AUG 1970

Pagination or Media Count : 39

Abstract : Thirty three novel 3-aryl-5-substituted-quinolines have been synthesized and characterized. Nine of these compounds have been submitted for antimalarial screening. Four compounds in this group were alpha-aminomethyl-3-aryl-5-quinoline- methanols with different substituents in the aromatic rings. Of those compounds in this group which have been tested, two (AV-96591 and AW-23879) show some activity against P. berghei infections in mice at s.c. dose levels of 160 mg/kg or lower. Reports on the phototoxicity of these compounds have not been issued. (Author)

Descriptors :   (*ANTIMALARIALS, *QUINOLINES), SYNTHESIS(CHEMISTRY), AMINES, CARBINOLS, HALOGENATED HYDROCARBONS, CHLORINE COMPOUNDS, BROMINE COMPOUNDS

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE