Accession Number : AD0714666

Title :   Gas Transport During Controlled Ventilation at Rest and Exercise.

Descriptive Note : Progress rept. no. 3 (Annual), 1 Oct 69-30 Sep 70,

Corporate Author : COLORADO UNIV DENVER MEDICAL CENTER

Personal Author(s) : Filley,Giles F.

Report Date : 01 OCT 1969

Pagination or Media Count : 60

Abstract : The altered hypoxic ventilatory drive in the native and non-native long term residents of high altitude was studied. The result indicates that hypoxic ventilatory drive is depressed in non-native residents of high altitude and that the degree of depression is a function of the length of time spent at high altitude. The same depression of hypoxic and hypercapnic drive was shown to take place in athletes. The decrease in ventilation and increase in PaCO2 produced in man and animals by morphine was also studied. In cats it was determined that morphine depresses hypoxic ventilatory drive and this effect is slightly accentuated if the usual morphine-induced increase in CO2 tension is prevented. A new steady state method for measuring Dco in the human lung was developed. A study was directed toward a determination of the relative contribution to airway stability of the airway structure and of the surrounding parenchyma. (Author)

Descriptors :   (*RESPIRATION, MASS TRANSFER), (*HYPOXIA, RESPIRATION), LUNG, EXERCISE(PHYSIOLOGY), BLOOD CIRCULATION, BLOOD VOLUME, DIFFUSION, GASES, CARBON DIOXIDE, OXYGEN, RESPIRATORY SYSTEM, TRANSPORT PROPERTIES, HIGH ALTITUDE

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE