Accession Number : AD0714682

Title :   Intestinal Digestion and Absorption of Sugars and Peptides.

Descriptive Note : Final scientific rept. 1 Apr 69-30 Jun 70,

Corporate Author : MILAN UNIV (ITALY) INST OF GENERAL PHYSIOLOGY

Personal Author(s) : Semenza,Giorgio

Report Date : 14 JUL 1970

Pagination or Media Count : 7

Abstract : The sucrase-isomaltase complex, as prepared from the small intestine by papain solubilisation and Sephadex chromatography, has a ml. wt. of approximately 190 000 and is composed of 6 subunits. Its amino acid composition, its content in SH and SS groups have been determined. The sucrase-isomaltase complex binds glucose reversibly. This binding requires Na(+) and is inhibited by a number of sugars and sugars analogues which are absorbed by the same transport system as glucose. Phlorizin is hydrolyzed by an enzyme bound to the brush borders. There is a close correlation between 'phlorizin hydrolase' activity and the extent of phlorizin inhibition of intestinal sugar transport. Preliminary evidence indicates that more than one carrier may be involved in the transport of 6-deoxy-D-glucose. (Author)

Descriptors :   (*SUCROSE, ABSORPTION(BIOLOGICAL)), (*PEPTIDES, ABSORPTION(BIOLOGICAL)), GASTROINTESTINAL SYSTEM, GLUCOSE, ENZYMES, BIOCHEMISTRY, PHYSIOLOGY, SWITZERLAND

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE