Accession Number : AD0714851

Title :   Interaction of Chlorpromazine and Tissue Binding Sites: Preliminary Studies.

Descriptive Note : Interim rept. Mar-Jun 70,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Bernardini,Albert T.

Report Date : NOV 1970

Pagination or Media Count : 12

Abstract : Minced tissue from various body components of rat were subjected to equilibrium dialysis after incubation with chlorpromazine (CPZ). Radioactive CPZ (35S-labeled) was used as a tracer. Tissue binding at low concentrations (0.8 to 3.4 micrograms/ml.) and higher concentrations (0.2 to 4 mg/ml.) demonstrated binding averages. At the higher incubation concentrations, a decrease in slope estimates indicated probable secondary binding sites. (Author)

Descriptors :   (*CHLORPROMAZINE, TISSUES(BIOLOGY)), (*DRUGS, *MOLECULAR ASSOCIATION), IN VITRO ANALYSIS, IN VIVO ANALYSIS, DOSAGE, RATS, TRACER STUDIES, EQUILIBRIUM(PHYSIOLOGY), DIALYSIS, PHARMACOLOGY, INTERACTIONS

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE