Accession Number : AD0715189

Title :   Gas-Liquid Chromatography of Caramiphen Hydrochloride and Its Analogues,

Corporate Author : DEFENCE RESEARCH ESTABLISHMENT OTTAWA (ONTARIO)

Personal Author(s) : Casselman,A. A. ; Bannard,R. A. B.

Report Date : 23 MAY 1970

Pagination or Media Count : 4

Abstract : Parpanit (Caramiphen hydrochloride, 2'-diethylaminoethyl I-phenylcyclopentanecarboxylate hydrochloride) and many of its analogues have been prepared and studied as possible antidotes for anticholinesterase poisoning. The feasibility of using gas-liquid chromatography both as a criterion of purity for these compounds and as a means for their quantitative analysis has been briefly examined. Hydrochloride salts of this type decompose to the corresponding free bases during GLC and consequently it is possible to determine quantitatively either the free base or hydrochloride by GLC analysis. (Author)

Descriptors :   (*GAS CHROMATOGRAPHY, *ESTERS), (*AMINES, GAS CHROMATOGRAPHY), CYCLOPENTANES, QUANTITATIVE ANALYSIS, PARASYMPATHOMIMETIC AGENTS, CANADA

Subject Categories : Pharmacology
      Physical Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE