Accession Number : AD0715366

Title :   Interactions Between Episomal and Between Episomal and Chromsomal Genes Controlling Drug Resistance in Bacteria (Vzanmodeistvie Episomnykh, Episomnykh i Khromosomnykh Genov, Kontroliruyushchikh Lekarstvennuyu Ustoichivost),

Corporate Author : ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER WASHINGTON D C

Personal Author(s) : Astapov,A. A.

Report Date : 03 SEP 1970

Pagination or Media Count : 14

Abstract : The results of the determinations of the phenotypical expression of genes responsible for drug resistance in the recombinants carrying a certain set of chromosomal and episomal genes responsible for the resistance to antibioties are described and discussed in this paper. The resistance to tetracycline (Tc) and chloramphenicol (Cm) of the resistant to these antibiotics multiple--step mutant of Escherichia coli, strain M that was acquired in the course of conjugation of a fi-R (PnCmTc) or a fi+R (CmTc) factor is much higher, than in the E. coli cells possessing only one of these R factors. The level of resistance to Tc and Cm of the E. coli recombinants carrying both factors, fi-R (PnCmTc) and fi+R (SmCmTc) is twice or three times as high, as that of the E. coli cells possessing only one of these R factors. The transfer, by means of conjugation, of the fi-R (PnCmTc) factor to the E. coli, recombinants carrying the fi-R (Pn) factor did not affect significantly the phenotypical manifestation of the resistance to penicillin (Pn) apparently in consequence of the elimination of one of heset episomal factors. The level of the resistance to Tc and Cm of the Schigella sonnei recombinants carrying the non-transferrable R (SmCmTcColMn) and the transferrable factor fi-R (PnCmTc) either remained unchanged or decreased. (Author)

Descriptors :   (*BACTERIA, DRUGS), (*DRUGS, TOLERANCES(PHYSIOLOGY)), (*GENETICS, BACTERIA), CHROMOSOMES, ANTIBIOTICS, ESCHERICHIA COLI, SHIGELLA SONNEI, TETRACYCLINES, PENICILLINS, CHLORAMPHEICOL, USSR

Subject Categories : Microbiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE