Accession Number : AD0715386
Title : Neurotropic Effects in Relation to Chemical Structure.
Descriptive Note : Quarterly rept. no. 1, 1 Jun-31 Aug 65,
Corporate Author : SAINT LOUIS UNIV MO
Personal Author(s) : Donahoe,Hugh B. ; Hufker,William J.
Report Date : 31 AUG 1965
Pagination or Media Count : 49
Abstract : Attempts were made to prepare both the endo and exo isomers of V. 1,4-dihydro-9, 10-dimethyl-1,4-ethanonaphthalene-2,3-dicarboxylic anhydride. Evidence for the isolation of a eutectic mixture of both is presented. A continuation of the syntheses and biological evaluations of substituted 11-aminomethyl-9,10-ethano-9,10-dihydro-anthracenes is also reported. The synthese of intermediates of a new series of dihydroanthracenes possessing a two-carbon side chain, 11-(alpha-hydroxy-beta-aminoethyl) -9,10-dihydroanthracene, are contained in this report. Continuation of the syntheses of the hydrochloride and methiodide salts of three series of 1-dialkylaminoacetyl-3-keto-1,2,3,4,-tetrahydroquinoxalines is also presented. (Author)
Descriptors : (*ANTISPASMODIC AGENTS, *MOLECULAR STRUCTURE), (*ANALGESICS + ANTIPYRETICS, MOLECULAR STRUCTURE), (*NITROGEN HETEROCYCLIC COMPOUNDS, SYNTHESIS(CHEMISTRY)), (*POLYCYCLIC COMPOUNDS, SYNTHESIS(CHEMISTRY)), MUSCLE RELAXANTS, ANTHRACENES, ANHYDRIDES, AMINES, MOLECULAR ISOMERISM
Subject Categories : Pharmacology
Distribution Statement : APPROVED FOR PUBLIC RELEASE