Accession Number : AD0715387

Title :   Neurotropic Effects in Relation to Chemical Structure.

Descriptive Note : Quarterly rept. no. 2, 1 Sep-30 Nov 65,

Corporate Author : SAINT LOUIS UNIV MO

Personal Author(s) : Donahoe,Hugh B. ; Hufker,William J.

Report Date : 30 NOV 1965

Pagination or Media Count : 34

Abstract : Attempts to prepare both the endo and exo isomers of 1,4-dihydro-9, 10-dimethyl-1,4-ethanonaphtalene-2,3-dicarboxylic anhydride at temperatures above 100 are presented. The completion of the synthesis and a continuation of the biological evaluation of substituted 11-aminomethyl-9, 10-ethano-9, 10-dihydroanthracene is also reported. The synthesis of aminoesters and aminoamides of 9,10-ethano-9, 10-dihydroanthracene-11-carboxylic acids is described. (Author)

Descriptors :   (*ANTISPASMODIC AGENTS, *MOLECULAR STRUCTURE), (*ANALGESICS + ANTIPYRETICS, MOLECULAR STRUCTURE), (*POLYCYCLIC COMPOUNDS, SYNTHESIS(CHEMISTRY)), MUSCLE RELAXANTS, ANTHRACENES, AMINES, CARBOXYLIC ACIDS, MOLECULAR ISOMERISM, AMIDES, ESTERS

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE