Accession Number : AD0715388

Title :   Neurotropic Effects in Relation to Chemical Structure.

Descriptive Note : Quarterly rept. no. 3, 1 Dec 65-28 Feb 66,

Corporate Author : SAINT LOUIS UNIV MO

Personal Author(s) : Donahoe,Hugh B. ; Hufker,William J.

Report Date : 28 FEB 1966

Pagination or Media Count : 53

Abstract : Further attempts were made to separate the endo and exo isomers of 1, 4-dihydro-9, 10-dimethyl-1,4-ethanonaphthalene-2-3-dicarboxylic anhydride. The completion of the synthesis of substituted 11-amino-methyl-9,10-ethano-9,10-dihydroanthracene is also reported. The synthesis of two new series of bicyclic compounds derived from 11-(beta-aminoethyl)-9,10-ethano-9,10-dihydroanthracene and 11-(aminoacetoxy)-9,10-ethano-9,10-dihydroanthracenes are listed. Acute toxicities of substituted 11-aminomethyl-9,10-ethano-9, 10-dihydroanthracenes,11-(beta-aminoethyl)-9,10-etnano-9,10-dihydroanthracenes and aminoesters and aminoamides of 9,10-ethano-9,10-dihyroanthracene-11-carboxylic acides were measured. The antispasmodic activities of substituted 4,9-0-benzobenz(f)isoindolines and 11-aminomethyl-9,10-ethano-9,10-dihydroanthracenes were also determined. (Author)

Descriptors :   (*ANTISPASMODIC AGENTS, *MOLECULAR STRUCTURE), (*TOXICITY, ANTISPASMODIC AGENTS), (*ANALGESICS + ANTIPYRETICS, MOLECULAR STRUCTURE), (*POLYCYCLIC COMPOUNDS, SYNTHESIS(CHEMISTRY)), MUSCLE RELAXANTS, BIOASSAY, MOLECULAR ISOMERISM, AMINES, CARBOXYLIC ACIDS, AMIDES, ESTERS, ANHYDRIDES, ANTHRACENES

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE