Accession Number : AD0715389

Title :   Neurotropic Effects in Relation to Chemical Structure.

Descriptive Note : Final rept. 1 Jun: 65-31 May 66,

Corporate Author : SAINT LOUIS UNIV MO

Personal Author(s) : Donahoe,Hugh B. ; Hufker,William J.

Report Date : 31 MAY 1966

Pagination or Media Count : 86

Abstract : The exo isomer of 1,4-dihydro-9,10-dimethyl-1,4-ethanonophthalen-2,3-dicarboxylic anhydride was isolated and characterized. Biologically testable derivatives were also prepared. Two series of 11-(omega-dialkylaminoalkyl)-9,10-ethano-9,10-dihydroanthracenes were synthesized and selected compounds were biologically screened. Three series of amino esters and amino amides derived from 9,10-ethano-9,10-dihydroanthracene derivatives were also reported. New types of bi-planar compounds having a phenolic diphenylmethane structure were prepared. Their analgesic activity was also determined. (Author)

Descriptors :   (*ANTISPASMODIC AGENTS, *MOLECULAR STRUCTURE), (*ANALGESICS + ANTIPYRETICS, MOLECULAR STRUCTURE), (*POLYCYCLIC COMPOUNDS, SYNTHESIS(CHEMISTRY)), (*TOXICITY, ANTISPASMODIC AGENTS), MUSCLE RELAXANTS, BIOASSAY, MOLECULAR ISOMERISM, POLYCYCLIC COMPOUNDS, ANHYDRIDES, AMINES, CARBOXYLIC ACIDS, AMIDES, ANTHRACENES, PHENOLS, NAPHTHALENES

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE