Accession Number : AD0715389
Title : Neurotropic Effects in Relation to Chemical Structure.
Descriptive Note : Final rept. 1 Jun: 65-31 May 66,
Corporate Author : SAINT LOUIS UNIV MO
Personal Author(s) : Donahoe,Hugh B. ; Hufker,William J.
Report Date : 31 MAY 1966
Pagination or Media Count : 86
Abstract : The exo isomer of 1,4-dihydro-9,10-dimethyl-1,4-ethanonophthalen-2,3-dicarboxylic anhydride was isolated and characterized. Biologically testable derivatives were also prepared. Two series of 11-(omega-dialkylaminoalkyl)-9,10-ethano-9,10-dihydroanthracenes were synthesized and selected compounds were biologically screened. Three series of amino esters and amino amides derived from 9,10-ethano-9,10-dihydroanthracene derivatives were also reported. New types of bi-planar compounds having a phenolic diphenylmethane structure were prepared. Their analgesic activity was also determined. (Author)
Descriptors : (*ANTISPASMODIC AGENTS, *MOLECULAR STRUCTURE), (*ANALGESICS + ANTIPYRETICS, MOLECULAR STRUCTURE), (*POLYCYCLIC COMPOUNDS, SYNTHESIS(CHEMISTRY)), (*TOXICITY, ANTISPASMODIC AGENTS), MUSCLE RELAXANTS, BIOASSAY, MOLECULAR ISOMERISM, POLYCYCLIC COMPOUNDS, ANHYDRIDES, AMINES, CARBOXYLIC ACIDS, AMIDES, ANTHRACENES, PHENOLS, NAPHTHALENES
Subject Categories : Pharmacology
Distribution Statement : APPROVED FOR PUBLIC RELEASE