Accession Number : AD0715398

Title :   Neurotropic Effects in Relation to Chemical Structure.

Descriptive Note : Quarterly rept. no. 3, 1 Feb-30 Apr 67,

Corporate Author : SAINT LOUIS UNIV MO

Personal Author(s) : Donahoe,Hugh B. ; Hufker,William J.

Report Date : 30 APR 1967

Pagination or Media Count : 20

Abstract : The resolution of 11-dimethylaminomethyl-9,10-ethano-9,10-dihydroanthracene into its enantiomorphs has been effected. The resolution of 11-N-piperidinomethyl-9,10-ethano-9,10-dihydroanthracene is in progress. The preparation of 2-p-hydroxyphenyl-2-p-aminophenylpropane is reported. Attempts to prepare intermediates for the synthesis of 11-aminomethyl-9,10-etheno-9,10-dihydroanthracenes are also described. The resolution of atropine into d- and l-hyocyamine is reported. The acute toxicities of twenty-five compounds prepared in these laboratories were measured. (Author)

Descriptors :   (*ANTISPASMODIC AGENTS, *MOLECULAR STRUCTURE), (*ANALGESICS + ANTIPYRETICS, MOLECULAR STRUCTURE), (*TOXICITY, ANTISPASMODIC AGENTS), (*POLYCYCLIC COMPOUNDS, SYNTHESIS(CHEMISTRY)), (*PHENOLS, SYNTHESIS(CHEMISTRY)), (*ATROPINE, *MOLECULAR ISOMERISM), BIOASSAY, AMINES, MUSCLE RELAXANTS, ANTHRACENES

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE