Accession Number : AD0715398
Title : Neurotropic Effects in Relation to Chemical Structure.
Descriptive Note : Quarterly rept. no. 3, 1 Feb-30 Apr 67,
Corporate Author : SAINT LOUIS UNIV MO
Personal Author(s) : Donahoe,Hugh B. ; Hufker,William J.
Report Date : 30 APR 1967
Pagination or Media Count : 20
Abstract : The resolution of 11-dimethylaminomethyl-9,10-ethano-9,10-dihydroanthracene into its enantiomorphs has been effected. The resolution of 11-N-piperidinomethyl-9,10-ethano-9,10-dihydroanthracene is in progress. The preparation of 2-p-hydroxyphenyl-2-p-aminophenylpropane is reported. Attempts to prepare intermediates for the synthesis of 11-aminomethyl-9,10-etheno-9,10-dihydroanthracenes are also described. The resolution of atropine into d- and l-hyocyamine is reported. The acute toxicities of twenty-five compounds prepared in these laboratories were measured. (Author)
Descriptors : (*ANTISPASMODIC AGENTS, *MOLECULAR STRUCTURE), (*ANALGESICS + ANTIPYRETICS, MOLECULAR STRUCTURE), (*TOXICITY, ANTISPASMODIC AGENTS), (*POLYCYCLIC COMPOUNDS, SYNTHESIS(CHEMISTRY)), (*PHENOLS, SYNTHESIS(CHEMISTRY)), (*ATROPINE, *MOLECULAR ISOMERISM), BIOASSAY, AMINES, MUSCLE RELAXANTS, ANTHRACENES
Subject Categories : Pharmacology
Distribution Statement : APPROVED FOR PUBLIC RELEASE