Accession Number : AD0715399

Title :   Neurotropic Effects in Relation to Chemical Structure.

Descriptive Note : Final rept. 1 Aug 66-31 Jul 67,

Corporate Author : SAINT LOUIS UNIV MO

Personal Author(s) : Donahoe,Hugh B. ; Fufker,William J.

Report Date : 31 JUL 1967

Pagination or Media Count : 46

Abstract : Derivatives of 11-aminoalky1-9-10-ethano-9,10-dihydroanthracene, 11-gamma-aminoproproxymethyl)-9,10-ethano-9,10-dihydroanthracene and 11-(gamma-aminorpopoxy)-9,10-ethano-9,10-dihydroanthracene were prepared. Also reported are efforts toward the synthesis of various bi-planar diphenylmethane derivatives. The resolution of atropine and N,N-dimethylamethyl-9,10-ethano-9,10-dihydroanthracene are described. The acute toxicities of 55 compounds are also listed. (Author)

Descriptors :   (*ANTISPASMODIC AGENTS, *MOLECULAR STRUCTURE), (*ANALGESICS + ANTIPYRETICS, MOLECULAR STRUCTURE), (*TOXICITY, ANALGESICS + ANTIPYRETICS), (*POLYCYCLIC COMPOUNDS, SYNTHESIS(CHEMISTRY)), (*ATROPINE, *MOLECULAR ISOMERISM), MUSCLE RELAXANTS, AMINES, BIOASSAY, ANTHRACENES, NITROGEN HETEROCYCLIC COMPOUNDS

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE