Accession Number : AD0715536

Title :   Urinary Excretion of Adrenal Hormones in Man. Effects of Ethanol Ingestion, and their Modification by Chlormethiazole,

Corporate Author : KAROLINSKA SJUKHUSET STOCKHOLM (SWEDEN) LAB FOR CLINICAL STRESS RESEARCH

Personal Author(s) : Brohult,Johan ; Levi,Lennart ; Reichard,Hans

Report Date : 1970

Pagination or Media Count : 9

Abstract : A large single dose of ethanol (approximately 500 ml brand whisky) was administered to nine young, healthy males. This stimulus provoked pronounced increases in adrenaline and noradrenaline excretion during and soon after the ethanol ingestion. Similarly, the hangover next morning was accompanied by marked increases in adrenaline and noradrenaline excretion levels, in addition to increased excretion rates of 17-hydroxycorticosteroids. In five subjects treated with 0.5 g chlormethiazole, the catecholamine increases during the hang-over period were significantly reduced. During the week following the ethanol ingestion, the increase in adrenal function tended to persist. Some theoretical and clinical implications of these findings are discussed and some indications in favour of a relationship between the emotional-behavioural and the physiological effects of ethanol ingestion are mentioned. (Author)

Descriptors :   (*ADRENAL CORTEX HORMONES, EXCRETION), (*ETHANOLS, INGESTION(PHYSIOLOGY)), (*THIAZOLES, ADRENAL CORTEX HORMONES), AUTONOMIC NERVOUS SYSTEM, EPINEPHRINE, LEVARTERENOL, EMOTIONS, BEHAVIOR, CORTICOSTEROID AGENTS, HORMONES, DRUGS, TRANQUILIZERS, SWEDEN

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE