Accession Number : AD0715696

Title :   Tissue Transplantation: The Universal Donor and Blood Group Antibodies.

Descriptive Note : Progress rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Camp,Frank R. , Jr. ; Kaplan,Harold S. ; Ellis,Frank R. ; Zmijewski,Chester M. ; Conte,Nicholas F.

Report Date : 22 JUL 1970

Pagination or Media Count : 14

Abstract : Compatibility problems encountered in selecting the group O universal blood donor are reviewed and considered with other antigenic factors that could influence the immunological success of organ transplant. Varous vaccines and parenterals were assayed for A and B blood group substance. The effects of those injectables containing A and/or B substance and used in immunization programs with group O universal donors were studied. The observations by various workers that 15-30% of patients requiring renal transplantation have detectable lymphocytotoxic antibodies at the time of transplantation have resulted in a plea for avoidance of sensitization of the HL-A antigens. Consideration is given to reports that A and B antigens play a significant role in graft rejection and, in this respect, to the problem posed by the group O universal donor who receives vaccination products containing A and/or B substance. (Author)

Descriptors :   (*TRANSPLANTATION, *TISSUES(BIOLOGY)), (*BLOOD GROUPS, TRANSPLANTATION), (*IMMUNOLOGY, TRANSPLANTATION), IMMUNITY, VACCINES, KIDNEYS, ANTIGENS + ANTIBODIES

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE