Accession Number : AD0715699

Title :   Preparation of a Coral Snake Antivenin From Goat Serum.

Descriptive Note : Final rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Kocholaty,Walter F. ; Bowles-Ledford,Edith ; Daly,Joyce G. ; Billings,Thomas A.

Report Date : 29 SEP 1970

Pagination or Media Count : 9

Abstract : A monovalent antivenin was prepared by immunizing goats with detoxified coral snake venom obtained by photooxidation with visible light in the presence of methylene blue. Goats inoculated with this attenuated venom produced an immunoglobulin which protected mice against many-fold doses of the unaltered venom. Neither local nor systemic effects were observed in goats or mice. The effective and harmless toxoid obtained could be used for active immunization, in suitable circumstances, as well as for the production of antisera for passive immunization or treatment of coral snakebites. (Author)

Descriptors :   (*VENOMS, ANTIGENS + ANTIBODIES), (*IMMUNE SERUMS, PREPARATION), BLOOD SERUM, GOATS, REPTILES, IMMUNOLOGY, POISONS, GAMMA GLOBULIN, IMMUNITY, DRUGS, BIOLOGICAL PRODUCTS

Subject Categories : Toxicology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE