Accession Number : AD0716009

Title :   Application of Water-Insoluble Complexes of Klininogenases, Inhibitors and Kininases to Kinin Research.

Descriptive Note : Technical rept.,

Corporate Author : OKLAHOMA UNIV MEDICAL CENTER OKLAHOMA CITY

Personal Author(s) : Seki,T. ; Yang,H. Y. T. ; Levin,Y. ; Jenssen,T. A. ; Erdos,E. G.

Report Date : 15 NOV 1970

Pagination or Media Count : 16

Abstract : A variety of methods have been available for coupling proteins with water-insoluble carriers. In one previous study trypsin was coupled to the copolymer of maleic anhydride and ethylene (EMA) using hexamethylenediamine as cross-linking agent. The proposed mechanism of action involves the binding of the enzyme covalently via the epsilon-amino group of lysine in the protein. Because many of the kininogenases and kininases are labile enzymes badly in need of stabilization, the authors started to study the feasibility of binding some of these enzymes and their inhibitors to water-insoluble carriers.

Descriptors :   (*ENZYMES, *COMPLEX COMPOUNDS), (*ENZYME INHIBITORS, COMPLEX COMPOUNDS), THERMAL STABILITY, SOLUBILITY, ADSORPTION, SOLUTIONS(MIXTURES), POLYMERS

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE