Accession Number : AD0717800

Title :   Effect of Metal Ions on Oxygen Toxicity.

Descriptive Note : Research paper,

Corporate Author : DEFENCE RESEARCH ESTABLISHMENT TORONTO DOWNSVIEW (ONTARIO)

Personal Author(s) : Radomski,M. W. ; Wood,J. W.

Report Date : 1970

Pagination or Media Count : 6

Abstract : The effect of the parenteral administration of various metal ions on the su ceptibility of rats to the toxic effects of oxygen at high pressures (OHP, 75 psig) has been studied. The incidence of seizures and degree of lung damage in the treated animals were monitored. Cobalt, potassium, and calcium were without effect on oxygen toxicity in the rat. Magnesium (0.5-2.0 mmoles/kg) strongly protected rats against OHP-seizures with zinc and manganese showing marginal protection. The anticonvulsant effect of magnesium was eliminated by simultaneous injection of calcium. The development of lung edema in the exposed animals was prevented by certain doses of manganese and zinc while magnesium had no effect on this syndrome. Although no cation tested was equally effective against both syndromes of oxygen toxicity, a mixed ion treatment of magnesium and manganese alleviated both convulsions and lung damage, (Author)

Descriptors :   (*OXYGEN, TOXICITY), IONS, METALS, HIGH PRESSURE, LUNG, DAMAGE, CONVULSIVE DISORDERS, PATHOLOGY, RESPIRATORY SYSTEM, POTASSIUM, CALCIUM, MAGNESIUM, MANGANESE, ZINC, COBALT

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE