Accession Number : AD0717862

Title :   Solution and Vapor Phase Transport of Various Esters in Callus and Stratum Corneum Conjunction Membranes.

Descriptive Note : Final rept.,

Corporate Author : WISCONSIN UNIV MADISON SCHOOL OF PHARMACY

Personal Author(s) : Wurster,Dale E.

Report Date : JAN 1967

Pagination or Media Count : 154

Abstract : A quantitative method has been used for obtaining the transport rates and the permeability coefficients, for methyl salicylate through anhydrous callous and methyl, ethyl and glycol salicylates through both anhydrous and hydrous stratum corneum conjunction membranes. Experiments were carried out using the same stratum corneum conjunction membranes at four different temperatures for each salicylate ester. The transport rates obtained in the vapor phase for the salicylate esters and the n-butyl acetate under anhydrous state of the membrane at 30C were compared with the transport rates obtained using the same test membranes in solution phase at 30C. For all of these agents studied it was found that the transport rates obtained in the solution phase were higher than the vapor phase transport. It was also found that when the same test membranes were used in the vapor phase transport studies that hydration of the membrane enhanced the transport rate.

Descriptors :   (*CHEMOTHERAPEUTIC AGENTS, SKIN(ANATOMY)), (*ESTERS, SKIN(ANATOMY)), (*SKIN(ANATOMY), PERMEABILITY), ABSORPTION(BIOLOGICAL), TRANSPORT PROPERTIES, DIFFUSION, VAPORS, SALICYLATES, ACETATES

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE