Accession Number : AD0718136
Title : The Role of the Central Nervous System Cholinergic Mechanisms in Behavior and Learning.
Descriptive Note : Rept. no. 7 (Final),
Corporate Author : FRIENDS MEDICAL AND SCIENTIFIC RESEARCH INST BALTIMORE MD LAB OF NEUROLOGICAL SCIENCES
Personal Author(s) : Black,Perry ; Spyropoulos,Pericles
Report Date : SEP 1966
Pagination or Media Count : 25
Abstract : The principal purpose of this study was to investigate the possible differential effects of LSD as a function of procedural variations in performance of delayed response tasks. In general, LSD was found to impair delayed response performance in the monkey. From the standpoint of dose-effect relationships, the results suggest a positive correlation between magnitude of dose and extent of functional impairment. A tendency toward rapidly developing tolerance was observed. A 'placebo effect' in response to the control agent (sterile water) was encountered in a significant number of monkeys.
Descriptors : (*LYSERGIC ACIDS, NEUROLOGY), (*REACTION(PSYCHOLOGY), LYSERGIC ACIDS), MONKEYS, TEST METHODS, TIME, DOSAGE, BEHAVIOR, CORRELATION TECHNIQUES, TOLERANCES(PHYSIOLOGY)
Subject Categories : Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE