Accession Number : AD0718136

Title :   The Role of the Central Nervous System Cholinergic Mechanisms in Behavior and Learning.

Descriptive Note : Rept. no. 7 (Final),

Corporate Author : FRIENDS MEDICAL AND SCIENTIFIC RESEARCH INST BALTIMORE MD LAB OF NEUROLOGICAL SCIENCES

Personal Author(s) : Black,Perry ; Spyropoulos,Pericles

Report Date : SEP 1966

Pagination or Media Count : 25

Abstract : The principal purpose of this study was to investigate the possible differential effects of LSD as a function of procedural variations in performance of delayed response tasks. In general, LSD was found to impair delayed response performance in the monkey. From the standpoint of dose-effect relationships, the results suggest a positive correlation between magnitude of dose and extent of functional impairment. A tendency toward rapidly developing tolerance was observed. A 'placebo effect' in response to the control agent (sterile water) was encountered in a significant number of monkeys.

Descriptors :   (*LYSERGIC ACIDS, NEUROLOGY), (*REACTION(PSYCHOLOGY), LYSERGIC ACIDS), MONKEYS, TEST METHODS, TIME, DOSAGE, BEHAVIOR, CORRELATION TECHNIQUES, TOLERANCES(PHYSIOLOGY)

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE