Accession Number : AD0718544

Title :   Common Steps in the Repair of Alkylation and Radiation Damage in Yeast,

Corporate Author : YORK UNIV TORONTO (ONTARIO) DEPT OF BIOLOGY

Personal Author(s) : Brendel,M. ; Khan,N. A. ; Haynes,R. H.

Report Date : 23 NOV 1969

Pagination or Media Count : 7

Abstract : Radiation sensitive mutants of Saccharomyces cerevisiae were exposed to the action of nitrogen mustard (NH2) and methyl methanesulfonate (MMS). Sensitivity to HN2 was found to be correlated with sensitivity to ultraviolet light, whereas sensitivity to MMS was found to be correlated with sensitivity to X-rays. One mutant strain that is sensitive to both UV and X-rays was found to be sensitive also to HN2 and MMS. The latter result shows that there exists a locus in yeast that controls the repair of DNA damaged by all four of these mutagens. (Author)

Descriptors :   (*YEASTS, *RADIATION EFFECTS), ALKYLATION, SULFONATES, NITROGEN MUSTARDS, SENSITIVITY, X RAYS, ULTRAVIOLET RADIATION, CANADA

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE