Accession Number : AD0719991

Title :   Stimulation of Mitotic Activity in Rat Bone Marrow and Thymus by Exogeneous Adenosine 3'5'-Monophosphate (Cyclic AMP),

Corporate Author : NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) DIV OF BIOLOGY

Personal Author(s) : Rixon,R. H. ; Whitfield,J. F. ; MacManus,J. P.

Report Date : 06 APR 1970

Pagination or Media Count : 8

Abstract : The intraperitoneal injection of adenosine 3'5'-monophosphate (cyclic AMP), or its dibutyryl derivative, into rats increased the number of bone marrow and thymus cells which entered mitosis during the first 6 h following administration. This stimulatory action was observed both in the presence and absence of the mitotic blocking agent, Colcemid. However, the mitogenic activity of these nucleotides was limited to doses between 4 and 6 mg/kg; 5 mg/kg was the most effective dose. The ability of cyclic AMP to increase the flow of cells into mitosis supports the view that this cyclic nucleotide is an intracellular initiator of cell proliferation in lymphoid and haematopoietic tissue. (Author)

Descriptors :   (*BONE MARROW, ADENOSINE PHOSPHATES), (*THYMUS, ADENOSINE PHOSPHATES), (*CELLS(BIOLOGY), *ADENOSINE PHOSPHATES), (*MITOSIS, CELLS(BIOLOGY)), RATS, CYTOLOGY, MEDICAL RESEARCH, RIBONUCLEIC ACIDS

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE