Accession Number : AD0719994

Title :   Primary Structure of alpha-Lytic Protease: a Bacterial Homologue of the Pancreatic Serine Proteases,

Corporate Author : NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) BIOCHEMISTRY LAB

Personal Author(s) : Olson,M. O. J. ; Nagabhushan,N. ; Dzwiniel,M. ; Smillie,L. B. ; Whitaker,D. R.

Report Date : 21 JUL 1970

Pagination or Media Count : 5

Abstract : Comparison of the amino-acid sequence of the bacterial alpha-lytic protease wit the mammalian pancreatic proteases shows homologies in the regions of the N-terminus, the single histidine, an aspartic acid residue, the active serine, and in the positions of the three disulphide bridges. The partial sequence of a trypsin-like enzyme from Streptomyces griseus provides further evidence for divergent evolution of this class of enzymes from a common ancestral gene. (Author)

Descriptors :   (*PEPTIDE HYDROLASES, *MOLECULAR STRUCTURE), (*GENETICS, PEPTIDE HYDROLASES), BACTERIA, PANCREAS, CANADA, MAMMALS

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE