Accession Number : AD0719998

Title :   Separation of Polythiadioxopiperazine Antibiotics by Thin-Layer Chromatography,

Corporate Author : NATIONAL RESEARCH COUNCIL OF CANADA HALIFAX (NOVA SCOTIA) ATLANTIC REGIONAL LAB

Personal Author(s) : Rahman,R. ; Safe,S. ; Taylor,A.

Report Date : 28 AUG 1970

Pagination or Media Count : 4

Abstract : In recent years the number of 2,5-epipolythia-3,6-dioxopiperazine antibiotics has increased significantly due to isolation of new members of the series and by chemical transformations of the naturally-occurring compounds. By extensive chemical and/or X-ray crystallographic investigations the structure of gliotoxin (I), sporidesmin (II, X = 2, R = OH) and dehydrogliotoxin (III, X = 2) was determined and other closely related compounds have since been isolated or synthesized. The report deals with the thin-layer chromatographic behavior of fifteen of these sulfur-containing compounds. The separation of polysulfides (II, X = 1, 2, 3, 4, R = OH) and (III, X = 1, 2, 3, 4) differing only in the number of sulfur atoms in the 2,5 bridge is particularly noted. (Author)

Descriptors :   (*ANTIBIOTICS, *THIN LAYER CHROMATOGRAPHY), (*NITROGEN HETEROCYCLIC COMPOUNDS, THIN LAYER CHROMATOGRAPHY), SULFUR HETEROCYCLIC COMPOUNDS, POLYCYCLIC COMPOUNDS, INDOLES, KETONES, CANADA

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE