Accession Number : AD0721720

Title :   The Interpretation of Current Voltage Relations Recorded from a Spherical Cell with a Single Microelectrode,

Corporate Author : CALIFORNIA UNIV LOS ANGELES DEPT OF MATHEMATICS

Personal Author(s) : Barcilon,Victor ; Eisenberg,R. S. ; Engel,E.

Report Date : JAN 1971

Pagination or Media Count : 42

Abstract : The paper presents an analysis of the potential recorded when one microelectrode is used both to apply current to and record potential from a spherical cell. There are three significant components of the potential: a component produced inside the microelectrode, a time independent component representing the spatially nonuniform flow of current in the immediate vicinity of the microelectrode, and a time-dependent spatially-uniform component representing the average potential across the cell membrane. the second component describes changes in membrance potential as well as potential drops in the interior of the cell, the importance of each factor being dependent on the location of the electrode. Simple expressions, derived by a theoretical treatment, are given for each component of potential. The implications for the interpretation of experimental results determined with the 'single electrode bridge' technique are discussed and an optimal balancing procedure is suggested. (Author)

Descriptors :   (*NERVE CELLS, ELECTRICAL PROPERTIES), ELECTROPHYSIOLOGY, ELECTRODES, STIMULATION(PHYSIOLOGY), NERVOUS SYSTEM, PHYSIOLOGY, CELLS(BIOLOGY), PROBES, MEMBRANES(BIOLOGY), EXPERIMENTAL DATA

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE