Accession Number : AD0721915

Title :   Endocrine and Pulmonary Response to Hemorrhagic Shock.

Descriptive Note : Annual progress rept.,

Corporate Author : BOSTON UNIV MASS SCHOOL OF MEDICINE

Personal Author(s) : Egdahl,Richard H. ; Hechtman,Herbert B.

Report Date : 30 JUN 1971

Pagination or Media Count : 35

Abstract : Corticosteroid clearance by the gastrointestinal tract was measured in dogs and monkeys. Differences in concentration in aortic and portal venous blood were found and percentage of corticosteroid removed was higher in animals during shock than in controls. Primate and dog models for electrical stimulation of the brain have been developed, in a program designed to provide the ability to both stimulate and record electrical activity from various parts of the brain during hemorrhagic shock. An early change following hemorrhagic shock is a deminution in the functional residual capacity. Hyperventilation tends to restore FRC but leads to respiratory alkalosis. Platelets may serve a useful role in the local regulation of ventilation perfusion ratios. Bacteria are actively and rapidly removed by the lung in at least two stages. Formulas are presented for the measure of resting lung volume, alveolar ventilation, ventilation perfusion ratios and anatomic shunting. (Author)

Descriptors :   (*SHOCK(PATHOLOGY), *ADRENAL CORTEX), (*RESPIRATORY SYSTEM, SHOCK(PATHOLOGY)), CORTICOSTEROID AGENTS, GASTROINTESTINAL SYSTEM, BRAIN, CELLS(BIOLOGY), ELECTROPHYSIOLOGY, RESPIRATION, LUNG, BLOOD PLATELETS, BACTERIA, DOGS, MONKEYS

Subject Categories : Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE