Accession Number : AD0723228

Title :   Detection and Analysis of Parpanit in Blood by Gas-Liquid Chromatography,

Corporate Author : DEFENCE RESEARCH ESTABLISHMENT OTTAWA (ONTARIO)

Personal Author(s) : Casselman,A. A. ; Bannard,R. A. B.

Report Date : 18 JUN 1970

Pagination or Media Count : 4

Abstract : A method has been developed for the extraction of Parpanit free base (caramiphen) from human blood and for determination of the drug by gas-liquid chromatography. The method is reliable and nearly quantitative but insufficiently sensitive for use in peak build-up and clearance studies in humans. Factors such as the age of the blood and time of contact of the drug with blood on the efficiency of recovery were examined. The Parpanit content of fresh rabbit blood could be measured accurately, but there was considerable variability in the results obtained with fresh blood from different rabbits. The drug was degraded or absorbed by contact with rabbit blood in vitro and in vivo, more rapidly by the serum than by the cells. (Author)

Descriptors :   (*PARASYMPATHOLYTIC AGENTS, *BLOOD ANALYSIS), GAS CHROMATOGRAPHY, AMINES, CYCLOPENTANES, CANADA

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE