Accession Number : AD0723230

Title :   Gamma-Radiolysis of Cysteine-Cysteamine Disulfide in Aqueous Solution,

Corporate Author : DEFENCE RESEARCH ESTABLISHMENT OTTAWA (ONTARIO)

Personal Author(s) : Purdie,J. W.

Report Date : 21 SEP 1970

Pagination or Media Count : 7

Abstract : Gamma-radiolysis of a mixed disulfide, cysteine-cysteamine disulfide, in unbuffered aqueous solution (0.3 mM) was investigated in the presence and absence of oxygen. The principal products were the thiols (cysteine and cysteamine), the corresponding sulfinic and sulfonic acids, the symmetrical disulfides (cystine and cystamine) and ammonia. Cystine and cystamine were formed in very high yields in deaerated solution;(G(CySSCy) about 15) but addition of oxygen reduced the yield sharply and it was inversely proportional to the oxygen concentration except at very low oxygen levels. In aerated solution G(CySSCy) = 0.8. These observations were attributed to a chain reaction which was suppressed by oxygen. In the case of proteins, it was concluded that although chain reactions between RS. radicals and protein disulfide bonds were possible, they should be inhibited by oxygen. (Author)

Descriptors :   (*SULFIDES, *RADIATION CHEMISTRY), (*THIOLS, RADIATION CHEMISTRY), FREE RADICALS, OXYGEN, AMINES, GAMMA RAYS, CANADA

Subject Categories : Radiation and Nuclear Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE