Accession Number : AD0726792

Title :   The Effect of Lidocaine on Twitch Potentiation and Repetitive Neural Activity Produced by Soman and Neostigmine,

Corporate Author : SASKATCHEWAN UNIV SASKATOON DEPT OF PHARMACOLOGY

Personal Author(s) : Lowndes,H. ; Johnson,D. D.

Report Date : 13 AUG 1970

Pagination or Media Count : 6

Abstract : Soman and neostigmine produce twitch potentiation in the isolated rat phrenic nerve - diaphragm preparation by initiating repetitive electrical activity at neuromuscular junctions. This is associated with repetitive impulses in the phrenic nerve. Lidocaine abolishes the repetitive firing in both the phrenic nerve and diaphragm. This effect is produced by concentrations of lidocaine that have no effect on normal neuromuscular function as indicated by the absence of an effect on normal twitch or tetanic responses. These results indicate that the mechanism by which lidocaine abolishes drug-induced twitch potentiation involves the presynaptic nerve terminals. (Author)

Descriptors :   (*ANESTHETICS, NEUROMUSCULAR TRANSMISSION), (*NEUROMUSCULAR TRANSMISSION, PARASYMPATHOMIMETIC AGENTS), (*PARASYMPATHOMIMETIC AGENTS, ANESTHETICS), (*GD AGENT, ANESTHETICS), NERVOUS SYSTEM DISEASES, NERVOUS SYSTEM, PHYSIOLOGY, PATHOLOGY, NERVE IMPULSES

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE