Accession Number : AD0730795

Title :   Synthesis of New Antimalerial Drugs (9-Anthracenemethanols).

Descriptive Note : Rept. no. 3 (Annual), 1 Apr 70-30 May 71,

Corporate Author : INTERNATIONAL MINERALS AND CHEMICAL CORP LIBERTYVILLE ILL

Personal Author(s) : Traxler,James T. ; Lira,E. Patrick ; Huffman,Clarence W.

Report Date : JUL 1971

Pagination or Media Count : 37

Abstract : The syntheses of three O-(2-di-n-alkylamino-1-hydroxyethyl)-10- haloanthracene hydrochlorides are described. Unsuccessful attempts were made to prepare the corresponding 3,6-dibromo-10-chloro-, 3,6-dibromo-, 3-trifluoromethyl-10-chloro-, 3,10-ditrifluoromethyl, and 3,10-dichloro- analogs. It was expected that all the substituted 9-anthraldehydes would react with dimethyl sulfonium methylide to form the desired substituted 9-anthrylethylene oxide intermediates. Unfortunately this reaction was only successful where the 9-anthraldehyde contained a 10 H, Br, or Cl. Data on the 10-chloro-dibutylamine derivative show this compound to be more active than either the corresponding unsubstituted compound or the halogenated 1- or 4-phenanthrene aminoalcohols synthesized previously. (Author)

Descriptors :   (*ANTIMALARIALS, SYNTHESIS(CHEMISTRY)), ANTHRACENES, METHANOLS, HALOGENATED HYDROCARBONS, CHLORINE COMPOUNDS, FLUORINE COMPOUNDS, AMINES, CARBOXYLIC ACIDS, CHEMICAL REACTIONS

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE