Accession Number : AD0730902

Title :   Cataracts Induced in Guinea Pigs by Acetone, Cyclohexanone, and Dimethyl Sulfoxide.

Descriptive Note : Technical rept. Aug 70-Feb 71,

Corporate Author : EDGEWOOD ARSENAL MD

Personal Author(s) : Rengstorff,Roy H. ; Petrali,John P. ; Sim,Van M.

Report Date : AUG 1971

Pagination or Media Count : 30

Abstract : Small multiple doses of acetone, byclohexanone, and dimethyl sulfoxide, administered either topically or subcutaneously on the backs of guinea pigs over a period of 3 to 8 weeks caused cataracts in 29 out of 120 animals. Lens changes began as early as 8 weeks and as late as 6 months. They consisted of subcapsular focal or extensive vacuolated areas extending from the periphery towards the center of the lens. The histological appearance of the lenses was similar to that of senile cataracts and some forms of diabetic cataracts. (Author)

Descriptors :   (*EYE, TOXICITY), (*SOLVENTS, EYE), ACETONES, CYCLOHEXANONES, SULFOXIDES, OPHTHALMOLOGY, GUINEA PIGS, EXPERIMENTAL DATA, HISTOLOGY, PATHOLOGY, DIABETES

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE