Accession Number : AD0731091

Title :   The Effect of 6-Mev X-Ray on Plasma-Reducing Substances in the Primate (Macaca Mulatta).

Descriptive Note : Final rept. Oct 70-Mar 71,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Beckman,Fred N. ; Craig,Dan J. ; Nathan,Marc A. ; Kinsley,Earl L.

Report Date : AUG 1971

Pagination or Media Count : 16

Abstract : Altered mammalian blood glucose levels following whole-body exposure to ionizing radiation have been well documented in the literature. Studies in the rat, guinea pig, and rabbit indicate that hyperglycemia follows irradiation after a period of hours to days. In contrast, in the primate, authors have reported either no response to ionizing radiation or an early glucose 'burst.' Experiments were therefore undertaken which demonstrate: an early rise (30 to 50 mg. %) of plasma-reducing substances within 14 minutes after the onset of 165 rads/min. of 6-Mev x-irradiation; and blockage of this rise by diphenhydramine and alpha-chloralose. It is postulated that the early hyperglycemic response observed in the primate is much more closely related to the cardiovascular changes which occur immediately following ionizing radiation exposure than they are to gluconeogenesis and glycogenesis. (Author)

Descriptors :   (*RADIATION EFFECTS, *GLUCOSE), WHOLE BODY IRRADIATION, PRIMATES, BLOOD DISEASES, BLOOD PLASMA

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE