Accession Number : AD0731782

Title :   Oxime Acetates: Substrates for Acetylcholinesterase.

Descriptive Note : Technical rept. Jul 68-Feb 71,

Corporate Author : EDGEWOOD ARSENAL MD

Personal Author(s) : Steinberg,George M. ; Berkowitz,Lewis M. ; Thomas,Norman C. ; Maddox,Jan P. ; Szafraniec,Linda L.

Report Date : SEP 1971

Pagination or Media Count : 19

Abstract : Oxime acetates function as typical substrates for acetylcholinesterase (AChE). Both syn 3- and syn 4-PAM acetates are rapidly hydrolyzed. Both are highly water soluble and give large changes in molar absorbance upon hydrolysis. Hence, they have potential utility for spectrophotometric studies with the enzyme. The prior configurational assignment of syn 4-PAMAc has been confirmed by nuclear magnetic resonance spectroscopy. Vicinal aliphatic dioxime diacetates are hydrolyzed by AChE, but quite slowly. (Author)

Descriptors :   (*ACETYLCHOLINESTERASE, SUBSTRATES), (*PARASYMPATHOMIMETIC AGENTS, *OXIMES), PYRIDINES, ACETATES, HYDROLYSIS, NUCLEAR MAGNETIC RESONANCE, REACTION KINETICS, CHEMICAL BONDS

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE