Accession Number : AD0732701

Title :   Acute Response to Acid-Base Stress in the Dog,

Corporate Author : RAND CORP SANTA MONICA CALIF

Personal Author(s) : Russell,C. D. ; Illickal,M. M. ; Maloney,J. V. , Jr. ; Roeher,H. D. ; DeLand,E. C.

Report Date : 1971

Pagination or Media Count : 36

Abstract : A crucial problem in the clinical treatment of variety of pathological states is determining the acid-base status of the patient. Usually the acid-base status of a sample of blood in vitro, determined by measuring the pH, P(CO2), and either the 'actual bicarbonate' or the 'base excess,' is used as an approximate index of the status of the body. The definition of a precise relation, however, between the buffering characteristics of the blood and of the total body cell mass would permit the status of the body to be determined accurately by the analysis of blood. This study derives the correlation between the arterial-blood composition and the acid-base status of the whole body over a range of experimental conditions in which both respiratory and metabolic status were changed simultaneously. A nomogram for estimating whole body base excess from the pH and p(CO2) of arterial blood has been constructed from experimental data obtained in 54 nephrectomized dogs subjected to hyperventilation, CO2 breathing, NaHCO3 infusion, HCl infusion, and NH4Cl infusion in varying combinations. The data correlation was assisted by a general theoretical model of fluid and electrolyte distribution in the whole body, implemented on a digital computer. (Author)

Descriptors :   (*ACID-BASE EQUILIBRIUM, *PATHOLOGY), (*BLOOD CHEMISTRY, ACID-BASE EQUILIBRIUM), DISEASES, THERAPY, PH, PHYSIOLOGY, ELECTROLYTES(PHYSIOLOGY), IN VITRO ANALYSIS, DOGS, EXPERIMENTAL DATA

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE