Accession Number : AD0734194

Title :   Chromatography of Some Quaternary Drugs on Columns of Sephadex G-10,

Corporate Author : DEFENCE STANDARDS LABS MARIBYRNONG (AUSTRALIA)

Personal Author(s) : Crone,H. D.

Report Date : 24 MAY 1971

Pagination or Media Count : 10

Abstract : The chromatographic behaviour of some pyridinium oximes and related quaternary drugs on columns of Sephadex G-10 was studied. Comparable data for the elution of some of the drugs from a CM-cellulose column were also obtained. Hydrogen bonding between the acidic hydroxyl groups and the Sephadex gel seemed to be the major controlling factor in the chromatography. Quaternary compounds not possessing hydroxyl groups or aromatic rings tended to be eluted rapidly without separation. The system worked well, however, for the separation of a range of quaternary drugs. (Author)

Descriptors :   (*PYRIDINES, *CHROMATOGRAPHIC ANALYSIS), OXIMES, SALTS, SOLVENT EXTRACTION, PH, AUSTRALIA

Subject Categories : Pharmacology
      Physical Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE