Accession Number : AD0734301
Title : The Relationship between Hemoglobin Function and Membrane Integrity in Erythrocytes during Cold Storage.
Descriptive Note : Interim rept.,
Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY
Personal Author(s) : Moor,Gerald L. ; Harrison,Joel H. ; Rau,Donald C.
Report Date : 21 SEP 1971
Pagination or Media Count : 13
Abstract : Whole human blood with and without the addition of adenine-inosine was stored for 42 days. Adenine-inosine was effective in maintaining hemoglobin function as shown by a continued high level of 2,3-DPG. Analysis of the erythrocyte membranes was carried out by chemical and physicochemical methods. It was shown that adenine-inosine treatment does not alter the rate of membrane deterioration, indicating that the maintenance of membrane integrity and hemoglobin function is a separate problem and each must be treated individually. The determining factor in long-term red cell preservation may well reside in membrane stabilization. (Author)
Descriptors : (*BLOOD, STORAGE), (*ERYTHROCYTES, PRESERVATION), ADENINE, NUCLEOSIDES, HEMOGLOBIN, MEMBRANES(BIOLOGY), STABILITY, PHYSIOLOGY
Subject Categories : Medical Facilities, Equipment and Supplies
Distribution Statement : APPROVED FOR PUBLIC RELEASE