Accession Number : AD0734301

Title :   The Relationship between Hemoglobin Function and Membrane Integrity in Erythrocytes during Cold Storage.

Descriptive Note : Interim rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Moor,Gerald L. ; Harrison,Joel H. ; Rau,Donald C.

Report Date : 21 SEP 1971

Pagination or Media Count : 13

Abstract : Whole human blood with and without the addition of adenine-inosine was stored for 42 days. Adenine-inosine was effective in maintaining hemoglobin function as shown by a continued high level of 2,3-DPG. Analysis of the erythrocyte membranes was carried out by chemical and physicochemical methods. It was shown that adenine-inosine treatment does not alter the rate of membrane deterioration, indicating that the maintenance of membrane integrity and hemoglobin function is a separate problem and each must be treated individually. The determining factor in long-term red cell preservation may well reside in membrane stabilization. (Author)

Descriptors :   (*BLOOD, STORAGE), (*ERYTHROCYTES, PRESERVATION), ADENINE, NUCLEOSIDES, HEMOGLOBIN, MEMBRANES(BIOLOGY), STABILITY, PHYSIOLOGY

Subject Categories : Medical Facilities, Equipment and Supplies

Distribution Statement : APPROVED FOR PUBLIC RELEASE