Accession Number : AD0734828

Title :   Reactivity of Some Nitrogen and Sulfur Mustards in Biologic Media.

Descriptive Note : Technical rept. Aug 65-May 71,

Corporate Author : EDGEWOOD ARSENAL MD

Personal Author(s) : Williamson,Charles E. ; Witten,Benjamin

Report Date : NOV 1971

Pagination or Media Count : 13

Abstract : Certain nitrogen and sulfur mustards bind readily to blood constituents, thereby positioning them at macromolecular binding sites of low polarity. Because cyclization to form aziridinium and sulfonium ions is difficult in these environments, their rates of disappearance are decreased, the extent of which depends upon the degree of binding and the polarity of the binding sites. Serum albumin and hemoglobin contain hydrophobic binding sites and produce the largest rate inhibitions when these mustards are introduced into whole blood. (Author)

Descriptors :   (*MUSTARD AGENTS, *BIOCHEMISTRY), DECOMPOSITION, SERUM ALBUMIN, HEMOGLOBIN, REACTION KINETICS

Subject Categories : Biochemistry
      Chemical, Biological and Radiological Warfare

Distribution Statement : APPROVED FOR PUBLIC RELEASE