Accession Number : AD0734879

Title :   Specific Action of Glucagon on the Embden-Meyerhof Chain in the Liver. Experiments on the Isolated Perfused Liver,

Corporate Author : MARBURG UNIV (WEST GERMANY) PHYSIOLOGISCH-CHEMISCHES INSTITUT

Personal Author(s) : Schimassek,H. ; Mitzkat,H. J.

Report Date : 21 MAR 1963

Pagination or Media Count : 15

Abstract : The well known effects of glucagon, namely hyperglycemia and an increased lactate and pyruvate turnover, are demonstrated on the isolated perfused rat liver. In control perfusion experiments the glucose-6-phosphate (G-6-P) and fructose-1,6-diphosphate (FDP) levels were not in agreement with data obtained in vivo. In vitro the G-6-P level is lower, while FDP is higher compared to in vivo measurements. Addition of glucagon in physiological concentrations to the perfusion medium brings the level of these substrates in the perfused liver to the in vivo level. In the presence of glucagon the G-6-P/FDP ratio is 20 to 5 without glucagon in control perfusions. The changes in the level of these substrates describes in the perfused liver are specific and distinct effects of glucagon. No other hormones which act on carbohydrate metabolism produce the same phenomena. The experiments demonstrate the hormonal control exercised by glucagon on the metabolic pathway between G-6-P and FDP. (Author)

Descriptors :   (*GLUCAGON, CARBOHYDRATES), (*CARBOHYDRATES, METABOLISM), PANCREATIC HORMONES, HORMONES, LACTATES, PYRUVATES, SACCHARIDE PHOSPHATES, LIVER, PHYSIOLOGY, HYPERGLYCEMIA, BIOCHEMISTRY, WEST GERMANY

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE