Accession Number : AD0736393

Title :   The Synthesis of Carbohydrate Derivatives of Importance in Biosynthesis.

Descriptive Note : Final technical rept. 1 Nov 70-31 Oct 71,

Corporate Author : UNIVERSITY COLL OF SWANSEA (WALES)

Personal Author(s) : Williams,J. M. ; Batey,J. F.

Report Date : NOV 1971

Pagination or Media Count : 24

Abstract : There is good evidence for the involvement of nucleoside diphosphate aldulose derivatives as intermediates in several important biochemical reactions. One such relation is the interconversion of D-glucose and D-galactose, this being considered to proceed via uridine diphosphate D-xylo-4'-hexosulose ('4-keto-D-glucose')1. The report describes the continuation of efforts to synthesise the above compound and the analogous 6'-deoxy compound. 1, 2, 3, 6-Tetra-O-benzoyl-alpha-D-glucopyranose has been obtained in good yield by selective benzoylation of alpha-D-glucose, and it is proposed that this tetrabenzoate be converted into the hexos=4=ulose dithioketal by means of the reactions used for the corresponding methyl glycoside.

Descriptors :   (*CARBOHYDRATES, *BIOSYNTHESIS), (*NUCLEOSIDES, SYNTHESIS(CHEMISTRY)), GLUCOSE, PHOSPHATES, ORGANIC SULFUR COMPOUNDS, KETONES

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE