Accession Number : AD0736715

Title :   Continued Studies on the Ontogeny of Mechanisms Controlling Protein Synthesis.

Descriptive Note : Final technical rept. 16 Aug 69-15 Sep 71,

Corporate Author : CALIFORNIA UNIV SANTA BARBARA

Personal Author(s) : Triplett,Edward L.

Report Date : 08 FEB 1972

Pagination or Media Count : 17

Abstract : The ultimate objective of this work has been to understand mechanisms that control the differentiation of cells derived from the embryonic neural plate. The principal products of this embryonic tissue are neurons, pigment cells, adrenal medullary cells and a variety of connective tissue cells. Since each of these cell types may be distinguished unambiguously by its special use of the amino acid tyrosine, we are, as a first step, trying to determine mechanisms that control tyrosine metabolism as a function of developmental stage. At the moment, special attention is being given to an enzyme that catalyzes the oxidations of tyrosine and dopa and dopamine. Experiments are being done to determine (1) control mechanisms in rates of synthesis and degradation of the enzyme and (2) conditions that dictate its substrate specificity. (Author)

Descriptors :   (*PROTEINS, BIOSYNTHESIS), (*TYROSINE, METABOLISM), (*NERVE CELLS, *EMBRYOLOGY), ADRENAL GLANDS, CELLS(BIOLOGY), ENZYMES, OXIDOREDUCTASES

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE