Accession Number : AD0737749

Title :   The Treatment of Acute Respiratory Failure in Experimental Fat Embolism.

Descriptive Note : Final rept.,

Corporate Author : COLORADO UNIV DENVER MEDICAL CENTER

Personal Author(s) : Ashbaugh,David G.

Report Date : 22 FEB 1972

Pagination or Media Count : 31

Abstract : Respiratory failure associated with experimental fat embolism was investigated using two experimental models and various therapeutic modalities. The canine oleic acid model of fat embolism was used primarily. In initial experiments it was determined that continuous positive pressure breathingg was more effective than intermittent positive pressure breathin in the treatment of respiratory failure caused by the injection of oleic acid. Corticosteroids seemed to have no particular beneficial effect in this model. This model was also investigated using in vivo observations via a thoracic window to determine alterations in pulmonary microanatomy after fat embolism. Two basic patterns were observed: one of complete vascular occlusion to an area of lung, and a second, of acute toxic vasculities with interstitial hemorrhage, edema, and loss of alveolar stability. Further experiments demonstrated a consumption coagulopathy in the canine oleic acid model and also demonstrated that fibrin was deposited in the pulmonary interstitium and arterioles following fat embolism. (Author)

Descriptors :   (*EMBOLISM, *RESPIRATORY SYSTEM), LUNG, RESPIRATION, PATHOLOGY, PRESSURE BREATHING, FATS, OXYGEN CONSUMPTION, CORTICOSTEROID AGENTS, CHEMOTHERAPY, OLEIC ACID, EXPERIMENTAL DATA, DOGS

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE