Accession Number : AD0739699

Title :   Some Effects of CBrF3 Inhalation and Epinephrine Challenge on Certain Myocardial Metabolite Levels.

Descriptive Note : Interim rept.,

Corporate Author : NAVAL AIR DEVELOPMENT CENTER WARMINSTER PA CREW SYSTEMS DEPT

Personal Author(s) : Rhoden,Richard A.

Report Date : 30 DEC 1971

Pagination or Media Count : 61

Abstract : Bromotrifluoromethane (CBrF3) would have considerable potential as a closed environment fire extinguishing agent, except for its membership in that large group of hydrocarbons capable of precipitating irregular heart action when inhaled by persons with elevated levels of blood epinephrine. These experiments were an effort to determine whether myocardial metabolism was impaired in male Wistar rats breathing 79/21 CBrF3/O2 and challenged with 1-epinephrine in what would ordinarily constitute sub-toxic dosages. CNS effects were the major observations in rats exposed to both CBrF3 and epinephrine; all control rats survived without apparent effect. The general picture was consistent with the CBrF3 induction of respiratory depression and hypoxia. (Author)

Descriptors :   (*HALOGENATED HYDROCARBONS, TOXICITY), (*CARDIOVASCULAR SYSTEM, HALOGENATED HYDROCARBONS), ARRHYTHMIA, RESPIRATION, EPINEPHRINE, CENTRAL NERVOUS SYSTEM, HYPOXIA, HEART, METABOLISM, FIRE EXTINGUISHERS

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE