Accession Number : AD0741381

Title :   Coagulation and Hemostatic Effects of Dextran and Other Macromolecules.

Descriptive Note : Rept. no. 2 (Final comprehensive), 1 Oct 68-30 Sep 71,

Corporate Author : NEW YORK BLOOD CENTER N Y

Personal Author(s) : Alexander,Benjamin

Report Date : 06 APR 1972

Pagination or Media Count : 32

Abstract : A major problem associated with the use of several colloids as plasma substitutes for blood replacement, blood volume expansion, resuscitory and other therapeutic purposes, is hemostatic failure in a certain percentage of human as well as animal recipients, first documented for dextran (D) by Crosby et al (1). This serious disadvantage has been similarly observed with several related and non-related macromolecular agents -- hydroxyethyl starch (HES), polyvinyl pyrrolidone (PVP), acacia, some of gelatin -- and, indeed, with large volumes of bank blood. The cause(s) of the hemostatic defect remains obscure. The objective was helping elucidate the underlying cause of this hemostatic failure. (Author)

Descriptors :   (*DEXTRAN, *BLOOD COAGULATION), (*BLOOD TRANSFUSION, *BLOOD PLASMA SUBSTITUTES), POLYSACCHARIDES, COLLOIDS, BLOOD PLASMA, FIBRINOGEN, FIBRIN, BLOOD PLATELETS

Subject Categories : Medicine and Medical Research
      Medical Facilities, Equipment and Supplies

Distribution Statement : APPROVED FOR PUBLIC RELEASE