Accession Number : AD0741814

Title :   Experimental Transfusion Reactions in Monkeys, Hemolytic, Coagulant, and Renal Effects of Transfused Isoimmune IgG and IgM.

Descriptive Note : Progress rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Lopas,Harry ; Birndorf,Norman I. ; Bell,C. Elliott , Jr. ; Robboy,StanleyJ. ; Fortwengler,H. Philip

Report Date : 24 JAN 1972

Pagination or Media Count : 21

Abstract : The study examines the role of the various agglutinin, hemolysin, and immunoglobulin species introducing changes in blood coagulation and renal function. Plasma from isoimmunized Macaca irus monkeys was fractionated into IgM and IgG. The effects of transfusion of these fractions on blood coagulation and renal function in incompatible recipients were studied. Only the hemolytic IgG fraction consistently resulted in hemolysis, and produced renal failure and the coagulation changes and autopsy findings characteristic of disseminated intravascular coagulation (DIC). The amount of hemolysis in vivo was accurately predictable by the QH50, a sensitive in vitro assay of antibody hemolytic activity. (Author)

Descriptors :   (*BLOOD TRANSFUSION, RESPONSE(BIOLOGY)), (*GAMMA GLOBULIN, BLOOD TRANSFUSION), BLOOD COAGULATION, KIDNEYS, HEMOLYSIS, ANTIGEN ANTIBODY REACTIONS, IMMUNOLOGY, BLOOD PLATELETS, FIBRIN, FIBRINOGEN, EXPERIMENTAL DATA, MONKEYS

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE